Most people are under the flawed opinion that handguns, especially small ones are only good for short range shots, especially with smaller firearms. I carried a Lady Smith in 357 for quite a few years. Practice was with 38 special target loads with zeros only confirmed with 357s. The recoil from the 357 was fierce and not something you would want to shoot on a regular basis, but if you were going to carry one, then you had to periodically have to fire a 357 round to remind you of the fact that you really had to hold on tight. I never tried shooting that revolver beyond 50 feet. The point of impact was around 5 inches higher than the 38 special rounds, something one needed to be aware of.
As for shooting a handgun at longer ranges, most of the people out on the range these days have fancy semi auto pistols that they shoot between 5 and 25 feet, and have trouble hitting a full size silhouette at those ranges. Competitive shooters routinely shoot out to 50 yards during competition. Even the comparatively slow moving 45 ACP does not drop that much between 25 and 50 yards. I have shot both my Gold Cup and Model 19 out at 100 yards, both are accurate enough to hit a man size target with ease at that range. Aim for the head and let gravity drop the round into the target, the 45 ACP will hit in the upper torso, the 357 will only drop to the lower neck upper body area. In Vietnam many an overconfident enemy soldier fell to a lowly 45 ACP at ranges beyond 25 feet. We would practice regularly at 50 yards and sometimes out to 100. As my Army hero, LTC Lones Wigger once said, "Only Hits Count!"